ABSTRACT. In the last decades of the nineteenth century, Mediterranean Countries have had to face the “global-grow phenomenon”, driven by financial and technological sectors. Such phenomenon triggered progress in productive, economic and technological fields, especially in the majority of the internal geographical areas. However, this improvement was not followed by a cultural and social growth in favour of people. Moreover, the high speed of changes did not allow the environmental adaptation required in many small communities. To switch from the theoretical framework to a concrete action, the MOTRIS development Program for the Mediterranean Regions has been drafted in 1999, funded by the Presidency of Sicily Government and held by the Italian-Egyptian Research Centre CRUEC together with several Euro-Mediterranean Partners.