ABSTRACT. This paper deals with the specific characteristics of Human Resource Management (HRM) in Small and Medium-sized Enterprises in the region of Western Saxony, Germany. Our research provides a descriptive and explorative analysis of HR processes in the regional Small and Medium-sized Enterprises (SMEs), their specific challenges and the status of Lifelong Learning (LLL). Thus, new insights and knowledge intended to contribute to research regarding HRM for SMEs were generated. The research results were obtained during the Erasmus+ project SHARPEN during which a collaborative cross-regions survey was conducted in five European countries from 2016-2019. This paper presents a review of the current literature relevant for HRM in (regional) SMEs as well as a discussion of the research results and recommendations for SMEs. It was found that the SMEs situated in Western Germany possess reasonably developed HR structures and processes and that Lifelong Learning initiatives are applied. For the benefit of the economic development of the region, offering ways to intensify the exchange of ideas and best practices as well as adopting theoretical constructs could allow the SMEs to gain new incentives for future projects.